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A caveat to consider is that the true prevalence of NASH is unclear, as diagnosis via biopsy is limited, with the majority of the data provided by US detection. Non-alcoholic steatohepatitis NASH is a more severe form of NAFLD, and is characterized by lobular inflammation and hepatocyte ballooning; 12 furthermore, NASH is presumed to lead to cirrhosis in a quarter of the afflicted patients. NASH is also associated with higher mortality from cardiovascular causes. The disease is characterized by a spectrum of liver steatosis fat depositioninflammation in NASH and fibrosis. In Bangladesh, a single published study conducted in a tertiary care liver clinic estimated a prevalence of It is worth noting that a study in London amongst the immigrant Bangladeshi population appeared to show an increased susceptibility to developing NAFLD as compared to Caucasians. This has also led to concerns regarding the use of nomenclature broadly to define obesity, which may not be accurate in the South Asian population. Emerging data is notable for high prevalence of NAFLD in South Asian populations, presumably resulting from a combination of underlying genetic polymorphisms and changes in socio-economic status.
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